TABLE 4

Pharmacokinetic parameters of VEN, ODV, and NDV in rats after oral administration of VEN alone or VEN combined with ZJP

AnalyteGroupsCmax (ng/ml)Tmax (h)t1/2 (h)CLz/F (l/h per kilogram)AUC024 (µg/l × h)
VENVEN3.47 ± 0.801.0 ± 0.62.4 ± 2.2231.7 ± 18.611.1 ± 0.9
VEN+ZJP2.01 ± 0.85*3.1 ± 1.8*4.0 ± 2.2198.7 ± 151.315.5 ± 7.6
ODVVEN4.82 ± 4.181.1 ± 0.96.2 ± 3.3172.7 ± 123.519.3 ± 11.3
VEN+ZJP3.41 ± 2.002.1 ± 1.410.9 ± 6.5116.8 ± 66.823.7 ± 12.8
NDVVEN1.24 ± 0.902.0 ± 1.85.1 ± 2.9468.0 ± 208.76.45 ± 4.34
VEN+ZJP1.91 ± 1.023.6 ± 2.26.1 ± 4.5215.4 ± 132.1*13.5 ± 5.7*
  • * P < 0.05 compared with VEN group. CLz/F, apparent oral clearance.