TABLE 3

In vitro TDI parameter estimates for MCA using numerical and replot methods

ParametersNumerical Method ModelsReplot Method
MIC-M-ILPI-M-ILEII-PI-M-ILa
AICc−583.95−608.48−636.53
R20.99800.99830.9986
kinact (min−1)b0.022 ± 0.0080.27 ± 0.06k6 = 0.71 ± 0.150.16 ± 0.03
k11 = 0.11 ± 0.02
KI,u (μM)bKI,u = 38.6 ± 12.6326.83 ± 8.30KI,u1 = 104.00 ± 27.5757.15 ± 15.38
KI,u2 = 5 (fixed)
  • a Two binding model.

  • b Estimated value ± S.E.