TABLE 4

Herb-drug interaction predictions for CA and MCA with nicotine and letrozole using KIu and kinact obtained using the numerical method and CYP2A6 half-life = 37 h

SubstrateInhibitorTDI Parameter Estimation MethodHerb-Drug Interaction Prediction (AUC-Fold Increase)
NicotineCAReplot4.21
Numerical4.29
MCAReplot4.31
Numerical4.35
LetrozoleCAReplot4.82
Numerical4.92
MCAReplot4.94
Numerical5.00