Enzymatic kinetics parameters of VEN in RLM, HLM, and rhCYP2D6s
| Subject | Km (μM) | Vmax (nmol/min per Milligram Protein or nmol/min per Picomoles P450) | CLint (μl/min per Milligram Protein or μl/min per Picomoles P450) |
|---|---|---|---|
| RLM | 41.2 ± 23.4 | 0.480 ± 0.013 | 11.7 ± 5.5 |
| HLM | 39.9 ± 1.1 | 0.182 ± 0.004 | 5.7 ± 0.2 |
| rhCYP2D6*1/*1 | 11.3 ± 3.2 | 0.014 ± 0.003 | 1.2 ± 0.3 |
| rhCYP2D6*10/*10 | 148.2 ± 26.5 | 0.013 ± 0.002 | 0.088 ± 0.016 |