TABLE 2

IC₅₀ and IC_50,u values for CBD, THC, 11-OH-THC, and COOH-THC against select CYP activities in HLMs

Data represent means ± S.D. of three independent experiments, each conducted in duplicate.

Enzyme	CBD		THC		11-OH-THC		COOH-THC^{^a}
Enzyme	IC₅₀ (μM)	IC_50,u (μM)	IC₅₀ (μM)	IC_50,u (μM)	IC₅₀ (μM)	IC_50,u (μM)	IC₅₀ (μM)
CYP1A2	3.76 ± 1.44	0.45 ± 0.17	1.26 ± 0.31	0.06 ± 0.02	13.49 ± 1.19	2.16 ± 0.19	>50
CYP2C9	1.43 ± 0.28	0.17 ± 0.03	0.23 ± 0.03	0.012 ± 0.001	2.68 ± 0.92	0.43 ± 0.15	>50
CYP2C19	2.58 ± 0.46	0.30 ± 0.06	11.44 ± 4.44	0.57 ± 0.22	13.1 ± 1.91	2.1 ± 0.31	>50
CYP2D6	7.88 ± 4.14	0.95 ± 0.50	25.5 ± 4.9	1.28 ± 0.25	39.2 ± 7.72	6.27 ± 1.24	>50
CYP3A	3.16 ± 0.96	0.38 ± 0.11	26.09 ± 6.78	1.30 ± 0.34	>50	>8	>50

↵^a Unable to determine because of inability to inhibit by >50% at concentration range tested.