Summary of contributed original research articles to this special issue of Drug Metabolism and Disposition that illustrate the use of various experimental approaches to assess the disposition, drug interaction potential, or hepatoprotective effects of select natural products and constituents

Natural product studiedCommon use(s)Biochemical target(s)Experimental system(s) or approachesAuthors
Common name(s)Latin nameConstituent(s) studied
Cannabis, marijuanaCannabis sativaCBD, THCMultipleCYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3AHLMsBansal et al.
ChrysinNAChrysin, chrysin-7-glucuronide, chrysin-7-sulfateAnxiety, depression, hypertension, maintaining testosterone levelsCYP2C9, CYP2C19, CYP2D6, CYP3A4, OATP1A2, OATP1B1, OATP1B3, OATP2B1, BCRP, MRP2, P-gpCypExpress kits; OATP-overexpressing A431 cells; BCRP-, MRP2-, and P-gp–expressing membrane vesiclesMohos et al.
CinnamonCinnamomum spp.Cinnamaldehyde, 2-methoxy-cinnamaldehydeCooking spice, glucose controlCYP2A6HLMs, purified CYP2A6Espiritu et al.
GoldensealHydrastis canadensisBerberine, (-)-β-hydrastine, hydrastinineCommon cold, upper respiratory tract infections, gastrointestinal disordersCYP2C9, CYP2D6, CYP3AHLMs, rCYP3A4, rCYP3A5McDonald et al.
Gotu kola, Indian pennywortCentella asiaticaNACognitive declineCYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 CYP2D6, CYP3AHLMs, human hepatocytesWright et al.
TurmericCurcuma longaCurcumin glucuronideCooking spice, chemoprevention, multiple othersMRP3Membrane vesicles, Mrp3 knockout and wild type miceJia et al.
Yan hu suo, corydalis, Asian corydalisCorydalis yanhusuoDehydrocorydalineCoronary heart, disease, analgesiaOCT1, OCT3, OCTN1, OCTN2, P-gpTransfected MDCK cells, primary neonatal rat cardiomyocytes, miceChen et al.
Zuojin pillRhizoma coptidis/Fructus evodiae (6:1 blend)Berberine, coptisine, evodiamine, rutaecarpineGastrointestinal disordersCYP2D6/Cyp2d1HLMs, rCYP2D6, RLMs, ratsLi et al.
NASchisandra chinensisLignansLiver diseasesMultipleMetabolomics, proteomics, lipidomicsYan et al.
MultipleMultipleNAMultipleCYP3ACryopreserved human intestinal mucosaLoretz et al.
  • CBD, cannabidiol; MDCK, Manine-Darby canine kidney; NA, not applicable; OCTN, organic cation/carnitine transporter; rCYP, recombinant P450; RLM, rat liver microsome; THC, (−)-trans-Δ9-tetrahydrocannabinol.