Kp,uu,lumbar CSF values of test compounds in the presence or absence of concomitant treatment with zosuquidar in cynomolgus monkeys
| Test Compounds | Unbound Plasma AUCa | CSF AUCa | Kp,uu,lumbar CSF | Kp,uu,lumbar CSF Ratio | |||
|---|---|---|---|---|---|---|---|
| Zosuquidar (−)b | Zosuquidar (+)c | Zosuquidar (−)b | Zosuquidar (+)c | Zosuquidar (−)b | Zosuquidar (+)c | Zosuquidar (+)/(−) | |
| Antipyrine | 2980 ± 1180 | 2870 (3120, 2650) | 3110 ± 1130 | 3080 (3290, 2870) | 1.05 ± 0.04 | 1.07 (1.05, 1.08) | 1.0 |
| Ondansetron | 586 ± 180 | 508 (752, 484) | 493 ± 110 | 653 (728, 578) | 0.861 ± 0.096 | 1.08 (0.968, 1.19) | 1.3 |
| Desloratadine | 515 ± 39 | 587 (619, 692) | 77.0 ± 8.5 | 163 (164, 163) | 0.151 ± 0.026 | 0.250 (0.264, 0.235) | 1.7 |
| Quinidine | 483 ± 181 | 363 (515, 332) | 114 ± 39 | 412 (472, 351) | 0.239 ± 0.011 | 0.987 (0.916, 1.06) | 4.1 |