TABLE 2

Pharmacokinetic parameters of total radioactivity ([3H]TAK-164 equivalents) after a single intravenous administration of 5 mg/kg [3H]TAK-164 to mice

Tumor and liver tissue parameters were calculated using extravascular dosing type. Plasma and blood parameters were calculated using intravenous dosing type.

MatrixDoseCmaxAUClastAUCAUC %ExtrapolatedCLt1/2
mg/kgμg-eq/ml or gh*μg-eq/ml or gh*μg-eq/ml or g%ml/h per kilogramh
Blood572.4349038409.21.3050.5
Plasma5116637067205.10.74541.2
Liver520.21330185828NCNC
Tumor532.93630552034NCNC
Tumor DNA50.68070.890.922NCNC
  • AUClast, area under concentration-time curve from 0 to time of the last quantifiable concentration; NC, not calculated. AUC % Extrap (% extrapolated), % area under concentration time curve from 0-infinity.