TABLE 1

Percent total radioactivity measured after treatment of GCC-expressing HEK-293 cells with [3H]TAK-164 and chKTI-[3H]IGN P1 (isotype control)

Percent Total Radioactivity
Cell ExtractMedia ExtractMedia PelletCell PelletDNA
0 h24 h0 h24 h0 h24 h0 h24 h0 h24 h
chKTI-[3H]IGN P10.250.284.412.7889.2090.656.146.300.331.57
[3H]TAK-1640.281.984.026.3875.3059.2920.4032.351.3512.31