TABLE 1

List of CES1 substrates

ACE (Adrenocortical Extract) Inhibitor	CNS (Central Nervous System) agents	Antihyperlidpidemia agents
Enalapril^{^a}	Methylphenidate	Clofibrate
Imidapril^{^a}	Cocaine	Fenofibrate
Benzapril^{^a}	Heroin
Quinapril^{^a}	Mepridine	Adrenal glucocorticoid
Ramipril^{^a}	Flumazenil	Ciclesonide^{^a}
Trandolapril^{^a}	Rufinamide
Antiviral agents	Anticancer agents	Chemical warfare agents
Oseltamivir^{^a}	Capecitabine^{^a}	Sarin
Sofosbuvir^{^a}	Irinotecan^{^a}	Soman
Tenofovir alafenamide^{^a}	Telotristat etiprate^{^a}	Tabun
Endogenous Compounds	Antiplatelets/anticoagulants	Pesticides
Cholesterol	Clopidogrel	Trans-permethrin
Fatty acid ethyl esters	Dabigatran^{^a}	Para-nitrophenyl valerate
Angiotensin receptor-neprilysin inhibitor (ARNi)	Immunosuppressive agents	Others
Sacubitril^{^a}	Mycophenolate mofetil^{^a}	Dimethyl fumarate^{^a}
		Oxybutynin

↵^a Prodrugs that need CES1 activation.