Mean (± S.D.) noncompartmental PK parameters of anti-Ly6E mAb and anti-Ly6E ADC in CB17 SCID mice and Sprague-Dawley rats
| Species | Treatment Dose, N | Cmax/Dose (µg/ml)/(mg/kg) | AUCINF/Dose (day•µg/ml)/(mg/kg) | AUCExtrap_PRED (%) | CL (ml/d per kilogram) | Vss (ml/kg) | t1/2 (day) |
|---|---|---|---|---|---|---|---|
| Mousea | anti-Ly6E mAb 1 mg/kg, n = 3 | 24.0 | 244 | 36.6 | 4.12 | 85.6 | 14.6 |
| Mousea | anti-Ly6E ADC 1 mg/kg, n = 3 | 26.1 | 300 | 31.4 | 3.33 | 59.7 | 11.7 |
| Rat | anti-Ly6E mAb 5 mg/kg, n = 4 | 25.2 ± 2.03 | 161 ± 63.2 | 14.7 ± 13.6 | 6.97 ± 2.60 | 79.6 ± 19.1 | 10.8 ± 5.94 |
| Rat | anti-Ly6E ADC 2 mg/kg, n = 5 | 28.2 ± 2.52 | 194 ± 84.3 | 22.0 ± 11.5 | 5.87 ± 1.88 | 68.5 ± 9.63 | 9.51 ± 4.02 |
AUCExtrap_PRED, percent of area under the concentration-time curve extrapolated from the last time point; t1/2, terminal half-life.
↵a Parameters were calculated using naïve pooling approach.