TABLE 2

Mean (± S.D.) noncompartmental PK parameters cynomolgus monkey anti-Ly6E ADC and anti-Ly6E mAb

Treatment	C_max (µg/ml)	C_max/Dose (kg•µg)/(ml/mg)	AUC_INF/Dose (day•µg/ml)/(mg/kg)	%AUC_Extrap__PRED (%)	CL (ml/d per kilogram)	V_ss (ml/kg)	t_1/2 (day)
Anti-Ly6E ADC (2 mg/kg, n = 3)^a	52.0 ± 12.2	26.0 ± 6.11	177 ± 35.7	16.0 ± 3.92	5.78 ± 1.10	61.3 ± 12.3	8.91 ± 0.907
Anti-Ly6E ADC (4 mg/kg, n = 6)^a	98.3 ± 20.6	26.0 ± 3.58	205 ± 43.3	20.7 ± 8.04	6.82 ± 1.13	62.6 ± 5.46	7.25 ± 1.02
Anti-Ly6E ADC (8 mg/kg, n = 1)^a^,^b	191	23.9	157	18.1	6.38	74.2	9.13
Anti-Ly6E mAb (0.3 mg/kg, n = 2)^b	9.31	31.0	222	7.92	4.51	71.2	11.9
Anti-Ly6E mAb (3 mg/kg, n = 3)	104 ± 11.7	34.6 ± 3.91	256 ± 14.0	7.53 ± 2.12	3.92 ± 0.221	60.2 ± 8.56	11.6 ± 1.18

AUC_Extrap__PRED, percent of area under the concentration-time curve extrapolated from the last time point; t_1/2, terminal half-life.
↵^a Parameters based on first cycle only.
↵^b S.D. was not calculated as n < 3.