TABLE 1

Comparing MPPGL-based scaling factors for mild, moderate, and severe cirrhosis relative to control from the current study with empirical scaling methodology

Population	Scalar from the Current Study (MPPGL__Population × Total Liver Volume__Population^{^a}) Relative to Healthy Population	Empirical Scalar (Healthy MPPGL × Functional Liver Volume__population) Relative to Healthy Population
Population		Johnson et al., 2010	Simcyp V18 and V19^b	Simcyp V20^{^b}
Healthy	1	1	1	1
Cirrhosis Child-Pugh A	0.74	0.81	0.89	0.86
Cirrhosis Child-Pugh B	0.77	0.65	0.71	0.71
Cirrhosis Child-Pugh C	0.57	0.53	0.61	0.59

↵^a From Ozaki et al. (2016).
↵^b Unpublished meta-analyses of literature functional liver volume data from imaging techniques (Lin et al., 1998; Zhu et al., 1999; Li et al., 2003; Shan et al., 2005; Reddy et al., 2018) via personal communication with Trevor Johnson, Simcyp, Sheffield, UK.