Effect of imeglimin at 1 mM on the MATE1 (metformin)-, MATE2-K (metformin)-, OAT1 (p-aminohippuric acid)-, and OAT3 (E3S)-mediated transport of substrate measured in the uptake transporter inhibition assay
| Transporter | Transporter-Specific Accumulation (cpm) | Relative Transporter-Specific Accumulation (% of Control) | Relative Inhibition (%) |
|---|---|---|---|
| MATE1 | 9.33 | 3.22 | 97 |
| MATE2-K | 186 | 61.6 | 38 |
| OAT1 | 2659 | 94.2 | 6 |
| OAT3 | 3160 | 90.7 | 9 |