Apparent paracellular permeability of [14C]imeglimin and reference substance [3H]cimetidine in Caco-2 cell monolayers (TC7-clone)
| Substrate | Concentration (µM) | Papp,A-B (10-6 cm⋅s−1) | Papp,A-B(EGTA) (10-6 cm⋅s−1) | Fparacell (%) |
|---|---|---|---|---|
| Imeglimin | 3 | 2.54 | 4.91 | 48.3 |
| 30 | 1.69 | 4.68 | 64.0 | |
| 300 | 0.720 | 5.13 | 86.0 | |
| Cimetidine | 10 | 0.132 | 2.92 | 95.5 |
Fparacell, contribution of the paracellular permeation to the overall permeation under the in vitro conditions of the model; Papp, apparent permeability.