TABLE 3

Half-maximal inhibitory concentration against YM155 uptake mediated by SLC35F2

Values represent IC50 of the compounds against 5 min YM155 (0.1 μM) uptake mediated by SLC35F2 in control PC-3 cells. Detailed data are presented in Supplemental Fig. 3. Values represent mean ± computer-calculated S.D. The experiments were repeated at least twice.

CompoundIC50
μM
Famotidine160 ± 28
Pyrilamine101 ± 27
Clonidine77.7 ± 14.6
Diphenhydramine65.7 ± 6.8
Imipramine17.2 ± 5.2
Quinidine4.01 ± 0.73