TABLE 4

Expression levels of phase III xenobiotic transporters in human skin and LabSkin

Protein identification and quantification was based on the presence of at least two different peptides and from human skin of at least two donors. Protein expression is represented by the mean, the S.D. of the mean (S.D.), the percent CV, the range (min–max), and the number of samples (n). Protein abundance is reported in picomole milligram−1 of protein.

ProteinHuman SkinLabSkin 1LabSkin 2
Mean ± S.D. (CV)Range (n)Median
ATP-binding cassette
 ABCA82.92 ± 0.97 (33.10)2.24–3.60 (2)2.92
 ABCB11a7.90 ± 2.03 (25.64)5.39–10.05 (4)8.094.994.81
Solute carriers
 SLC12A23.31 ± 0.80 (24.24)2.43–4.52 (5)3.072.10
 SLC25A3b4.92 ± 1.85 (37.65)2.98–7.23 (4)4.742.84
 SLC25A55.50 ± 1.27 (23.00)4.61–6.40 (2)5.50
 SLC25A63.50 ± 1.79 (51.19)1.46–4.82 (3)4.214.16
 SLC29A15.77 ± 0.79 (13.70)5.21–6.32 (2)5.77
 SLC44A1b3.75 ± 2.24 (59.81)2.29–6.34 (3)2.633.62
 SLC44A2b4.71 ± 1.89 (40.22)3.37–6.04 (2)4.71
 SLC4A1a4.94 ± 0.92 (18.64)4.22–6.20 (4)4.671.65
  • a According to Human Protein Atlas, these transporters are not reported to be present in the skin at the RNA or protein level.

  • b According to Human Protein Atlas, these transporters are reported to be present in the skin at the RNA level (low copy numbers) but not at the protein level.