TABLE 2

Relative exposures of lemborexant and its metabolites in AUC-pooled plasma

Individual plasma samples from eight subjects were mixed at equal volume, and a single AUC-pooled plasma sample was prepared from pooled samples collected from 0 to 96 h postdose.

AnalyteM No.Total Drug-Related Exposure
%
Met11.1
Met21.2
Met31.6
Met52.8
Met73.2
Met82.2
Met11-22.0
Met12M186.0
Met16-2M131.6
Met17M201.5
Met181.4
Met21aM11b, M14b3.0
Met23M152.6
Met24-1M123.1
Met24-2M46.3
Met26-2M96.6
Met27M1012.5
Lemborexant26.5
  • —, not applicable.

  • a Met21 was a mixture of Met21-1 and Met21-2.

  • b Met21-1 and Met21-2 were identified as M11 and M14.