TABLE 3

Inhibitory effects of compound 1 (10 μM) on CYP1A2, CYP2B6, and CYP3A enzyme activities in both reversible and time-dependent inhibitions in human microsomes

Mechanism% Inhibitiona
CYP1A2CYP2B6CYP3A
Reversible inhibition4.02.4−3.2
Time-dependent inhibitionb−7.2−2.3−10.7

  • ↵a Each value represents the mean (n = 3).

  • b The time-dependent inhibition was indicated as the difference in the percent inhibition between with and without the first incubation.