Conditions/Compounds | Conc. | Control YM155 Uptake (%) | |
---|---|---|---|
PC-3 | hCMEC/D3 | ||
Control | Free | 100 ± 6 | 100 ± 8 |
SLC35F2 knockout | 10.3 ± 1.0** | N.D. | |
l-carnitine | 1 mM | 125 ± 14** | 120 ± 4* |
TEA | 83.4 ± 1.8 | 64.2 ± 4.9** | |
Varenicline | 76.4 ± 3.0** | 84.3 ± 10.4 | |
Famotidine | 16.4 ± 1.8** | 15.1 ± 0.6** | |
Tramadol | 13.0 ± 1.0** | 32.6 ± 5.6** | |
Clonidine | 9.06 ± 0.47** | 21.9 ± 1.3** | |
Diphenhydramine | 5.65 ± 0.32** | 12.4 ± 0.7** | |
Pyrilamine | 5.46 ± 0.97** | 14.1 ± 1.3** | |
Imipramine | 5.36 ± 0.34** | 34.4 ± 2.5** | |
Verapamil | 100 μM | 5.11 ± 0.28** | 27.0 ± 6.1** |
Quinidine | 3.22 ± 0.51** | 15.1 ± 0.6** |
↵* P < 0.05; **P < 0.01 vs. control.