TABLE 2

Concentration of BMP in rat tissues with corresponding fractional volumes of lysosomes

Liver was taken as reference, whose lysosomal content was determined experimentally. Other tissues were calculated relative to the liver by bis(monoacylglycero)phosphate tissue concentrations.

TissueBMP Concentration aFractional Tissue Volume of Lysosomes (%)
pmol/mg tissue
Blood cells<LLOQbn.a.
Plasma<LLOQbn.a.
Adipose0.3 ± 0.10.03
Brain15 ± 1.91.4
Gutc14 ± 6.81.2
Heart3.5 ± 0.60.32
Intestine15 ± 6.01.4
Intestine large9.6 ± 1.90.88
Kidney19 ± 2.61.7
Liver14 ± 3.51.3
Lung17 ± 5.71.5
Muscle1.2 ± 0.10.11
Skin1.8 ± 0.60.16
Spleen58 ± 4.85.3
Stomach12 ± 1.91.1

  • ↵a Taken from Wang and Schmitt et al. (2019); data represent means ± S.D.

  • ↵b Lower limit of quantification.

  • ↵c Gut represents the weighted mean of small and large intestine accounting for the 2.3× higher volume of the small intestine.