TABLE 1

Tissue-specific input parameters to predict the unbound tissue partitioning and unbound volume of distribution (Vuss) in rats, which comprises the fractional tissues volumes of Rodgers et al. (2005) extended by a lysosomal compartment

	Fractional Tissue Volume^{^a}					Tissue Concentration of AP	Tissue Volume
Tissue	NL	NP	EW	IW^{^b}	Lysosomes^{^c}	Tissue Concentration of AP	Tissue Volume
						mg/g	ml
Ref.	[^{^d}]	[^{^d}]	[^{^d}]			[^{^d}]	[^{^e}]
Blood cells	0.0017	0.0029	n.a.	0.603	n.a.	0.5
Adipose	0.853	0.0016	0.135	0.017	0.00027	0.4	10.43
Bone	0.017	0.0017	0.1	0.346	n.d.	0.67	16.47
Brain	0.039	0.0015	0.162	0.606	0.0136	0.4	1.3
Gut	0.038	0.0125	0.282	0.463	0.0122	2.41	11.1
Heart	0.014	0.0111	0.32	0.453	0.0032	2.25	1.08
Kidney	0.012	0.0242	0.273	0.466	0.0173	5.03	2.85
Liver	0.014	0.024	0.161	0.560	0.0125	4.56	14.67
Lung	0.022	0.0128	0.336	0.431	0.0151	3.91	1.53
Muscle	0.01	0.0072	0.118	0.629	0.0011	1.53	136.24
Pancreas	0.041	0.0093	0.12	0.664	n.d.	1.67	0.94
Skin	0.06	0.0044	0.382	0.289	0.0016	1.32	43.69
Spleen	0.0077	0.0113	0.207	0.526	0.0527	3.18	0.83
Thymus	0.017	0.0092	0.15	0.626	n.d.	2.3	0.73
Plasma	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	8.13

n.a., not available; n.d., not determined.
↵^a Based on the tissue wet weight.
↵^b Fractional tissue volume of intracellular water of Rodgers et al. (2005) reduced by new lysosomal compartment.
↵^c Calculated by subtracting the fractional volume of extracellular water of the liver from total tissue volume and subsequently multiplying by the previously determined fractional volume of lysosomes in hepatocytes (Schmitt et al., 2019). Fractional volumes of tissues were scaled from liver by their BMP content.
↵^d Rodgers et al. (2005).
↵^e Rodgers and Rowland (2007).