Fold increase in predicted Kpu of 27 basic lipophilic drugs in rat tissues by incorporating lysosomal trapping into the mechanistic model compared with Rodgers et al. (2005) (eq. 2 vs. eq. 3)
| Tissue | Fold Increase of Kpu Minimum to Maximum (mean) |
|---|---|
| Adipose | 1.00–1.08 (1.01) |
| Brain | 1.01–1.81 (1.31) |
| Gut | 1.00–1.72 (1.11) |
| Heart | 1.00–1.20 (1.03) |
| Kidney | 1.00–2.09 (1.11) |
| Liver | 1.00–1.74 (1.08) |
| Lung | 1.00–1.94 (1.11) |
| Muscle | 1.00–1.06 (1.01) |
| Skin | 1.00–1.11 (1.02) |
| Spleen | 1.01–4.09 (1.43) |