TABLE 2

Summary of percent positive induction response (> 2-fold E_max) at 6, 12, 24, 48, or 72 h after treatment with prototypical inducers

Each value represents the percentage of donors yielding an E_max >2-fold at each time point.

Isoform	INDUCER	Donors with >2-Fold Induction at Each Time Point
		6		12		24		48		72
		mRNA	Activity	mRNA	Activity	mRNA	Activity	mRNA	Activity	mRNA	Activity
		%
CYP1A2	Omeprazole	67	25	75	67	100	100	100	100	100	100
CYP1A2	Phenobarbital	40	50	80	75	60	75	67	100	57	86
CYP2B6	Efavirenz	86	0	100	0	100	0	100	100	83	100
	Phenobarbital	86	50	100	60	100	100	100	100	100	100
	Rifampicin	67	50	100	75	83	83	100	100	100	100
CYP2C9	Rifampicin	0	ND	33	ND	75	ND	100	ND	100	ND
CYP3A4	Efavirenz	60	33	100	100	100	100	100	100	100	100
	Rifampicin	100	0	100	80	100	100	100	100	100	100
		Donors with >10-Fold Induction at Each Time Point
	Rifampicin	20	0	83	0	100	33	86	17	86	50