TABLE 1

Comparison of mechanistic tissue partitioning (Kp) prediction methods

MechanismsPoulin HomogeneousBerezhkovskiyRogers and RowlandLukacovaTrapp Intracellular
Albumin bindingYesYesYesYesNo
Neutral phospholipid bindingYesYesYesYesNo
Neutral lipid bindingYesYesYesYesNo
Acidic phospholipid bindingNoNoYesYesNo
Cytosolic ion partitioningNoNoYesYesYes
Lysosomal ion trappingNoNoNoNoYes
Mitochondria ion partitioningNoNoNoNoYes
Membrane potentialNoNoNoNoYes
Intracellular waterYesYesYesYesYes
Extracellular waterYesYesYesYesNo
Tissue-specific compositionYesYesYesYesNo