Comparison of mechanistic tissue partitioning (Kp) prediction methods
| Mechanisms | Poulin Homogeneous | Berezhkovskiy | Rogers and Rowland | Lukacova | Trapp Intracellular |
|---|---|---|---|---|---|
| Albumin binding | Yes | Yes | Yes | Yes | No |
| Neutral phospholipid binding | Yes | Yes | Yes | Yes | No |
| Neutral lipid binding | Yes | Yes | Yes | Yes | No |
| Acidic phospholipid binding | No | No | Yes | Yes | No |
| Cytosolic ion partitioning | No | No | Yes | Yes | Yes |
| Lysosomal ion trapping | No | No | No | No | Yes |
| Mitochondria ion partitioning | No | No | No | No | Yes |
| Membrane potential | No | No | No | No | Yes |
| Intracellular water | Yes | Yes | Yes | Yes | Yes |
| Extracellular water | Yes | Yes | Yes | Yes | No |
| Tissue-specific composition | Yes | Yes | Yes | Yes | No |