TABLE 4

Performance of VD,ss prediction methods utilizing adipocyte and myocyte Kp experimental data

Method DescriptionInput ParametersnWithin 2-FoldWithin 3-FoldWithin 10-Foldr2AAFE
%
Kp fat onlyKp adipocyte, fup and BPR1895468970.422.4
Kp muscle onlyKp myocyte, fup and BPR1894165940.432.6
Kp fat and muscleKp adipocyte, Kp myocyte, fup and BPR1893663920.462.9
Kp average of fat and muscleKp adipocyte, Kp myocyte, fup and BPR1893146830.463.9
Kp fat and Kp muscle with mechanistic predicted Kp values for other tissuesKp adipocyte, Kp myocyte, fup and BPR, predicted Kp values using ATOM mechanistic models for tissues other than fat and muscle1893356930.483.1
Kp fat and Kp muscle with mechanistic predicted Kp values for other tissues using experimental log DKp adipocyte, Kp myocyte, fup and BPR, predicted Kp values using ATOM mechanistic models for tissues other than fat and muscle1692746850.413.9
Lukacova with experimental fup, BPRExperimental fup and BPR. Other input parameters were predicted by ATOM ML models1896076950.502.2