TABLE 1

OATP1B1/2B1/1B3- and NTCP-mediated CL_{int,uptake,cells} of [³H]RSV based on their total or PMA in the transporter-expressing cells

Transporter (Cells)	Transporter-Mediated CL_{int,uptake,cells} of RSV (µl/min per Milligram Cellular Protein)^{^a}	Total Transporter Abundance (pmol/mg Cellular Protein) in Cells^{^b}	Transporter-Mediated RSV CL_{int,uptake,cells} (µl/min per Picomole Total Transporter Protein)	PMA of Transporter (% Total)^{^c}	Transporter-Mediated RSV CL_{int,uptake,cells} (µl/min per Picomole PM Transporter Protein)
OATP1B1 (CHO cells)	40.1	7.53	5.32	79.7 ± 4.7^{^d}	6.68
OATP1B3 (HEK293 cells)	28.6	6.23	4.60	63.2 ± 1.6^{^d}	7.27
OATP2B1 (MDCKII cells)	1.2	0.95	1.22	37.1 ± 15.7^{^d}	3.29
NTCP (HEK293 cells)	34.8	3.29	10.58	77.4	13.65

↵^a Data from a single experiment mean of triplicate determinations (except NTCP, avg. of duplicate determinations). The CL_{int,uptake,OATP1B1} of RSV obtained in OATP1B1-expressing CHO cells was confirmed with CL_{int,uptake,OATP1B1} of RSV in OATP1B1-expressing HEK293 cells.
↵^b Data are mean of duplicate determinations from a single experiment.
↵^c Data shown are mean of triplicates or mean ± S.D. of three independent experiments (except NTCP, which is mean of two independent determinations).
↵^d From Kumar et al. (2017).