CL values estimated by noncompartmental and compartmental analyses based on 4- and 24-h intravenous infusion studies
Each value was normalized to the CL of intravenous bolus data and then shown as avg. fold difference. The actual mean CL values for each group were shown in the bracket (milliliter per minute per kilogram).
| Internal Compounds | Commercial Compounds | Total | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| A | B | C | D | Atenolol | Loperamide | Minoxidil | NFPS | Sulpiride | Avg. | CV% | |
| NCA | |||||||||||
| Intravenous bolus | 1 (28.0) | 1 (31.3) | 1 (7.44) | 1 (3.29) | 1 (35.5) | 1 (22.5) | 1 (113.4) | 1 (18.4) | 1 (82.9) | 1 | 0 |
| NCA | |||||||||||
| 1 mg/kg over 4 h | 0.81 (22.6) | 1.12 (35.1) | 1.22 (9.10) | 4.48 (14.7) | 1.61 (57.3) | 4.55 (103) | 0.99 (113) | 2.78 (51.1) | 1.30 (108) | 2.10 | 70.8 |
| 1 mg/kg over 24 h | 0.71 (19.9) | 2.49 (77.9) | 0.76 (5.66) | 1.40 (4.62) | 1.27 (45.0) | 3.10 (69.9) | 0.90 (101.6) | 1.22 (22.4) | 1.15 (95.0) | 1.44 | 56.4 |
| 6 mg/kg over 24 h | 0.85 (23.9) | 2.05 (64.1) | 1.02 (7.61) | 1.26 (4.14) | 0.65 (23.0) | 3.03 (68.3) | 0.62 (70.4) | 0.66 (12.1) | 0.62 (51.1) | 1.19 | 69.3 |
| One-compartment analysis | |||||||||||
| 1 mg/kg over 4 h | 0.57 (16.1) | 0.99 (31.0) | 0.61 (4.58) | 3.57 (11.7) | 1.66 (59.0) | 4.07 (91.8) | 1.02 (116) | 2.56 (47.1) | 1.29 (107) | 1.81 | 71.0 |
| 1 mg/kg over 24 h | 0.73 (20.5) | 2.29 (71.7) | 0.83 (6.20) | 1.21 (3.98) | 1.23 (43.7) | 3.29 (74.2) | 0.90 (102.5) | 1.16 (21.4) | 1.11 (91.7) | 1.42 | 58.9 |
| 6 mg/kg over 24 h | 0.89 (25.0) | 1.42 (44.4) | 1.01 (7.54) | 0.86 (2.84) | 0.68 (24.0) | 2.91 (65.6) | 0.61 (68.8) | 0.61 (11.1) | 0.62 (51.6) | 1.07 | 69.2 |
| Two-compartment analysis | |||||||||||
| 1 mg/kg over 4 h | 0.57 (16.0) | 0.99 (31.0) | 0.61 (4.54) | 3.92 (12.9) | 1.53 (54.3) | 4.07 (91.8) | 0.89 (101) | 2.55 (47.0) | 1.27 (106) | 1.82 | 75.1 |
| 1 mg/kg over 24 h | 0.70 (19.7) | 2.14 (66.9) | 0.62 (4.60) | 0.87 (2.88) | 1.23 (43.6) | 2.87 (64.6) | 0.90 (102.4) | 1.16 (21.3) | 1.11 (91.7) | 1.29 | 57.4 |
| 6 mg/kg over 24 h | 0.83 (23.2) | 1.42 (44.4) | 0.98 (7.30) | 0.64 (2.09) | 0.66 (23.4) | 3.85 (86.9) | 0.60 (68.1) | 0.60 (11.1) | 0.61 (50.8) | 1.13 | 93.1 |