IC50 values of raloxifene, hydralazine, and WIN18,446 measured against recombinant AOX and ALDH1A1 enzymes (mean ± S.D., n = 3)
The selectivity index was calculated by dividing the IC50 value of the nontarget enzyme by the IC50 value of the target enzyme.
| AOX | ALDH1A1 | Selectivity index | |
|---|---|---|---|
| Raloxifene (μM) | 0.15 ± 0.05 | 1.54 ± 0.54 | 10.3 |
| Hydralazine (μM) | 0.42 ± 0.21 | 1840 ± 690 | 4381 |
| WIN18,446 (μM) | >500 | 0.102a | >4900 |
a The IC50 value is from Arnold et al. (2015b).