IC50 values of raloxifene, hydralazine, and WIN18,446 measured against recombinant AOX and ALDH1A1 enzymes (mean ± S.D., n = 3)

The selectivity index was calculated by dividing the IC50 value of the nontarget enzyme by the IC50 value of the target enzyme.

AOXALDH1A1Selectivity index
Raloxifene (μM)0.15 ± 0.051.54 ± 0.5410.3
Hydralazine (μM)0.42 ± 0.211840 ± 6904381
WIN18,446 (μM)>5000.102a>4900
  • a The IC50 value is from Arnold et al. (2015b).