Rosuvastatin | Pravastatin | Pitavastatin | Valsartan | Repaglinide | ||||||
---|---|---|---|---|---|---|---|---|---|---|
PXB | SCID | PXB | SCID | PXB | SCID | PXB | SCID | PXB | SCID | |
Fu plasma (%) | 7.14 ± 0.50 | 12.2 ± 2.5 | 37.0a | 71.0 ± 7.9 | 1.05 ± 0.27 | 2.67 ± 0.47 | 0.37 ± 0.13 | 4.03 ± 0.66 | 0.85 ± 0.19 | 1.67 ± 0.66 |
Fu liver (%) | 19.1 ± 4.0 | 23.2 ± 2.6 | 27.6 ± 8.2 | 39.8 ± 4.8 | 2.05 ± 0.52 | 2.74 ± 0.20 | 16.2 ± 8.5 | 21.8 ± 4.1 | 0.64 ± 0.12 | 0.62 ± 0.08 |
↵a Pooled sample of plasma from three animals.