TABLE 2

Disposition of E7766 in BDC rat and dog after intravenous bolus administration

DoseBDC Rat Intravenous Bolus, 1 mg/kgDog Intravenous Bolus, 0.075 mg/kg
CLtot,p (l/h per kilogram)6.50 ± 0.4291.29 ± 0.369
Vss (l/kg)2.47 ± 0.8490.553 ± 0.345
Ae renal (%)13.7 ± 2.804.96 ± 4.37
CLrenal (l/h per kilogram)0.895 ± 0.1890.0528 ± 0.0293
Ae biliary (%)92.1 ± 7.2687.9 ± 30.5
CLbiliary (l/h per kilogram)6.04 ± 0.7981.19 ± 0.637
Ae fecal (%)0.366 ± 0.208
CLfecal (l/h per kilogram)0.0227 ± 0.0138
  • Values represent the mean ± S.D. (n = 4 for BDC rats and n = 3 for dogs).