Unbound plasma and liver drug concentrations of rosuvastatin, pravastatin, pitavastatin, valsartan, and repaglinide in PXB and SCID mice in liver-to-plasma Kpuu studies with tissues collected at Tmax (h)
Data are means ± S.D.
| Rosuvastatin | Pravastatin | Pitavastatin | Valsartan | Repaglinide | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PXB | SCID | PXB | SCID | PXB | SCID | PXB | SCID | PXB | SCID | |
| Unbound plasma (ng/ml) | 7.20 ± 2.70 | 17.1 ± 12.5 | 38.1 ± 13.8 | 23.6 ± 17.3 | 0.25 ± 0.12 | 0.47 ± 0.20 | 9.64 ± 5.92 | 4.74 ± 1.88 | 0.58 ± 0.12 | 1.73 ± 0.90 |
| Unbound liver (ng/g) | 167 ± 56 | 4572 ± 3417 | 169 ± 89 | 2871 ± 1239 | 4.02 ± 2.71 | 8.37 ± 3.04 | 791 ± 460 | 198 ± 136 | 1.58 ± 0.46 | 2.46 ± 1.16 |