Inhibition of CYP2C8 and CYP3A4 by candesartan and its glucuronides, as related to paclitaxel metabolism
| Metabolite | CYP2C8 | CYP3A4 | ||
|---|---|---|---|---|
| IC50 | 95% CI | IC50 | 95% CI | |
| µM | µM | |||
| Candesartan | 150 | 123–176 | >250 | |
| N2-glucuronide | 166 | 135–197 | 191 | 125–257 |
| Acyl-β-D-glucuronide | 18.9 | 18.2–19.7 | 159 | 145–172 |