TABLE 2

FIM values from the CGNM-based PBPK modeling of the clinical bosentan data sets, which excluded the indicated bosentan intravenous doses

Information content of the indicated data set was quantified by the determinant of the FIM. The presented values are the median natural log-transformed values of the determinant of FIM calculated at the estimated parameter sets by the CGNM with the SSR values less than 2.30

Dose excluded (mg)FIM for target binding–related parameters (Kd, koff, XTotalR)
None (all doses used)11.0
10−40.8
10 and 50−42.6
750−1.85
750 and 500−0.456