TABLE 1

Physiologic parameters for human, cyno, dog, rat, and mouse

SpeciesVpVtR1 (Acid, Neutral, Zwitterion)R1 (Base)
l/kgl/kg
Human0.0430.5570.1160.052
Cyno0.04480.61960.1160.052
Dog0.05150.51360.1160.052
Rat0.03320.6140.1160.052
Mouse0.050.640.1160.052