TABLE 2

Pharmacokinetic parameters of cannabidiol in the fetal brain, liver, and GI tract

The results of the analysis are displayed as means ± S.D. Numerical data are expressed as means ± S.D. The significance of differences was evaluated using ANOVA, followed by Tukey’s test (AUC0–12, MRT0–12, t1/2α). The Student’s t test was used for the significant difference in t1/2β between brain and liver.

Fetal SampleAUC0–12AUCinfMRT0–12MRTinft1/2αt1/2β
ng*h/g tissueh
Brain (n = 15)1078.4 ± 72.31224.3 ± 138.92.2 ± 0.34.7 ± 1.40.8 ± 0.17.2 ± 2.4
Liver (n = 15)1519.2 ± 154.31572.3 ± 164.71.6 ± 0.042.2 ± 0.080.7 ± 0.14.2 ± 0.4
GI tract (n = 15)668.8 ± 52.11150.7 ± 218.62.2 ± 0.210.5 ± 4.51.1 ± 0.1a
Brain × liverP < 0.0001bN.S.bN.S.P < 0.0001
Brain × GI tractP = 0.0001bN.S.bN.S.
Liver × GI tractP < 0.0001bN.S.bN.S.
  • a Can't calculate.

  • b Not analyzed.