TABLE 1

Protein abundance scores of SLCO1B1 variants from ExAC Browser and Mayo Right 10K Study

EXACT cDNAEXACT Amino acidRSIDCommon Allele NameAllele FrequencyRight 10K (Variant Prevalence)DMS
WTHeterozygousHomozygousFunctional StudyAbundance Score
c.1296C>Ap.Asn432Lysrs5349318240.000108Severely Damaging0.5728
c.1828C>Tp.Arg610Cysrs7488606105.77E-051008220Severely Damaging0.5679
c.1246G>Ap.Val416Metrs774682761.66E-05Severely Damaging0.5225
c.1462G>Ap.Gly488Serrs7744715641.65E-05Severely Damaging0.3205
c.1508A>Gp.Asn503Serrs3684232441.65E-05Severely Damaging0.5332
c.215G>Ap.Ser72Asnrs7806862828.77E-06Severely Damaging0.5322
c.388A>Gp.Asn130Asprs2306283SLCO1B1*1B0.4795352549201639Damaging0.5768
c.1200C>Gp.Phe400Leurs59113707SLCO1B1*270.004341Damaging0.6015
c.169C>Tp.Arg57Trprs139257324SLCO1B1*330.000108Damaging0.5848
c.671T>Ap.Phe224Tyrrs7564318177.42E-05Damaging0.5925
c.1015G>Cp.Val339Leurs758315826SLCO1B1*613.42E-05Damaging0.577
c.235C>Tp.Leu79Phers3701300363.40E-05Damaging0.5867
c.695A>Cp.Lys232Thrrs3743286473.30E-05Damaging0.594
c.38C>Ap.Ala13Glurs7782141742.49E-05Damaging0.5994
c.593A>Gp.Asp198Glyrs3767552112.47E-05Damaging0.5944
c.991A>Gp.Ser331Glyrs7748452001.79E-05Damaging0.5875
c.1796G>Ap.Cys599Tyrrs5314881361.65E-05Damaging0.5799
c.154A>Gp.Ile52Valrs7628748021.65E-05Damaging0.5984
c.521T>Cp.Val174Alars4149056SLCO1B1*50.129470572768259TOLERATED0.7167
c.463C>Ap.Pro155Thrrs11045819SLCO1B1*40.116671812656247TOLERATED0.6718
c.1929A>Cp.Leu643Phers34671512SLCO1B1*190.04632907498624TOLERATED0.7172
c.733A>Gp.Ile245Valrs11045852SLCO1B1*240.007622TOLERATED0.6492
c.633A>Gp.Ile211Metrs2017225210.0040071007491TOLERATED0.7314
c.1463G>Cp.Gly488Alars59502379SLCO1B1*90.003196TOLERATED0.6747
c.1495A>Gp.Ile499Valrs740642130.002482TOLERATED0.6654
c.664A>Gp.Ile222Valrs79135870SLCO1B1*290.00099TOLERATED0.7112
c.317T>Cp.Ile106Thrrs2002275600.0006931007680TOLERATED0.6273
c.758G>Ap.Arg253Glnrs11045853SLCO1B1*250.000421008310TOLERATED0.6323
c.170G>Ap.Arg57Glnrs617601820.0003561008310TOLERATED0.7455
c.452A>Gp.Asn151Serrs2306282SLCO1B1 *160.000347TOLERATED0.6227
c.1034C>Tp.Thr345Metrs617602430.0002531008220TOLERATED0.6214
c.2032C>Tp.His678Tyrrs200995543SLCO1B1*340.000249TOLERATED0.6821
c.1309G>Ap.Gly437Argrs142965323SLCO1B1*260.00021007860TOLERATED0.6296
c.1622A>Tp.Gln541Leurs715819880.000132TOLERATED0.6445
c.2045C>Tp.Ser682Phers140790673SLCO1B1*280.000108TOLERATED0.6382
c.1007C>Gp.Pro336Argrs725597470.0001041008310TOLERATED0.634
c.1732G>Ap.Val578Ilers2010012699.10E-051008310TOLERATED0.6291
c.1322C>Ap.Thr441Asnrs1417792968.38E-05TOLERATED0.6661
c.1226A>Gp.Lys409Argrs1998593848.32E-05TOLERATED0.7054
c.1373A>Tp.Tyr458Phers7507985037.44E-05TOLERATED0.687
c.601A>Gp.Lys201Glurs5569143587.42E-05TOLERATED0.6046
c.518A>Gp.Tyr173Cysrs1414675437.42E-05TOLERATED0.6644
c.1213G>Ap.Val405Ilers3760601516.67E-05TOLERATED0.6274
c.1865C>Tp.Ser622Leurs3680524406.65E-05TOLERATED0.6501
c.638A>Gp.Asn213Serrs3724774516.61E-051008310TOLERATED0.6644
c.455G>Cp.Arg152Thrrs1451441295.79E-05TOLERATED0.7588
c.639T>Ap.Asn213Lysrs7528976635.78E-05TOLERATED0.6908
c.542G>Ap.Arg181Hisrs1421016905.77E-05TOLERATED0.7027
c.211G>Ap.Gly71Argrs3733275285.18E-051008130TOLERATED0.7462
c.1080C>Gp.Phe360Leurs1406744434.99E-05TOLERATED0.6719
c.66A>Tp.Arg22Serrs1420875294.99E-05TOLERATED0.71
c.410C>Tp.Ser137Leurs1512044654.96E-051008310TOLERATED0.659
c.152C>Tp.Ser51Phers7699001864.96E-05TOLERATED0.7129
c.577C>Tp.Leu193Phers3769965804.95E-05TOLERATED0.6597
c.1978G>Cp.Glu660Glnrs3684437404.20E-05TOLERATED0.6279
c.1178G>Ap.Gly393Glurs7681543424.19E-05TOLERATED0.6814
c.380C>Gp.Thr127Serrs569028384SLCO1B1*334.14E-051008310TOLERATED0.7218
c.298G>Ap.Gly100Serrs1445085504.13E-05TOLERATED0.6233
c.850A>Gp.Asn284Asprs7790595724.12E-05TOLERATED0.651
c.508A>Tp.Met170Leurs7648167114.12E-05TOLERATED0.6552
c.238G>Tp.Val80Leurs7810210723.39E-05TOLERATED0.6433
c.1739G>Ap.Arg580Glnrs7639919083.31E-05TOLERATED0.6099
c.385A>Gp.Ile129Valrs7596917733.31E-05TOLERATED0.6807
c.1573C>Tp.Pro525Serrs715819873.30E-05TOLERATED0.6178
c.766G>Ap.Gly256Argrs7542479323.30E-05TOLERATED0.6289
c.728G>Ap.Ser243Asnrs5580732763.30E-05TOLERATED0.6366
c.485G>Ap.Cys162Tyrrs1383746840.0000331008310TOLERATED0.6533
c.1829G>Ap.Arg610Hisrs7695185880.000033TOLERATED0.6645
c.743C>Tp.Thr248Ilers7743981333.30E-05TOLERATED0.6676
c.703G>Ap.Val235Metrs1474211600.0000331008220TOLERATED0.6918
c.106C>Tp.Leu36Phers7517670043.30E-05TOLERATED0.7133
c.992G>Ap.Ser331Asnrs7603139692.68E-051008220TOLERATED0.6478
c.212G>Ap.Gly71Glurs5407230562.61E-05TOLERATED0.7123
c.250G>Tp.Val84Leurs7500315412.52E-05TOLERATED0.6253
c.1878G>Cp.Leu626Phers2005269722.51E-051008310TOLERATED0.6499
c.1087G>Ap.Val363Ilers7647823822.49E-051008310TOLERATED0.6104
c.1742C>Tp.Ala581Valrs7513092542.49E-05TOLERATED0.6202
c.944G>Ap.Gly315Glurs3736193792.49E-05TOLERATED0.6837
c.904A>Tp.Asn302Tyrrs7708549762.48E-05TOLERATED0.6022
c.314G>Tp.Gly105Valrs7734341652.48E-05TOLERATED0.6312
c.629G>Tp.Gly210Valrs7664179542.48E-05TOLERATED0.6446
c.1671G>Ap.Met557Ilers7704204842.48E-05TOLERATED0.6606
c.1441T>Cp.Tyr481Hisrs7457089562.48E-051008310TOLERATED0.6722
c.1444A>Gp.Ile482Valrs7694281172.48E-05TOLERATED0.7065
c.1729A>Gp.Met577Valrs3711020232.48E-05TOLERATED0.7287
c.778C>Tp.Leu260Phers7569555112.47E-05TOLERATED0.6275
c.1793C>Tp.Thr598Metrs2018619912.47E-051008220TOLERATED0.6285
c.598G>Ap.Ala200Thrrs5401122242.47E-05TOLERATED0.6502
c.541C>Tp.Arg181Cysrs1389653662.47E-05TOLERATED0.6519
c.1616C>Tp.Ala539Valrs558485740SLCO1B1*462.47E-05TOLERATED0.6642
c.875C>Tp.Ala292Valrs7786428232.47E-05TOLERATED0.6772
c.1784T>Cp.Ile595Thrrs1390260942.47E-05TOLERATED0.7203
c.1564G>Tp.Gly522Cysrs1129099482.47E-05TOLERATED0.7355
c.981G>Tp.Gln327His1.90E-05TOLERATED0.6342
c.986T>Gp.Phe329Cysrs7644973271.84E-05TOLERATED0.6703
c.1966A>Gp.Ile656Valrs7572191271.69E-05TOLERATED0.635
c.1159G>Ap.Ala387Thrrs7750827871.69E-05TOLERATED0.6456
c.1319T>Gp.Met440Argrs139797371SLCO1B1*431.68E-051008220TOLERATED0.682
c.1298A>Gp.Lys433Argrs7720572641.67E-05TOLERATED0.639
c.193C>Gp.Leu65Valrs7668957711.67E-051008220TOLERATED0.6759
c.1214T>Cp.Val405Ala1.67E-05TOLERATED0.6979
c.1100A>Gp.Tyr367Cysrs7570367081.66E-05TOLERATED0.6216
c.481G>Ap.Gly161Serrs7493569961.66E-05TOLERATED0.6364
c.1076T>Cp.Val359Alars1477501181.66E-05TOLERATED0.6436
c.47C>Tp.Ser16Leurs7536181721.66E-05TOLERATED0.7199
c.128T>Cp.Leu43Prors7704725611.65E-05TOLERATED0.6088
c.1729A>Cp.Met577Leurs3711020231.65E-05TOLERATED0.6142
c.1628T>Gp.Leu543Trprs726611371.65E-05TOLERATED0.6165
c.1765A>Gp.Ile589Valrs7796743731.65E-05TOLERATED0.6209
c.529G>Cp.Gly177Argrs7502348711.65E-05TOLERATED0.6362
c.395C>Tp.Ser132Leurs7634296081.65E-05TOLERATED0.6368
c.560C>Tp.Pro187Leurs7791957541.65E-05TOLERATED0.641
c.1384G>Ap.Asp462Asnrs7786558081.65E-05TOLERATED0.6418
c.674C>Tp.Thr225Ilers3709438691.65E-05TOLERATED0.6468
c.1784T>Gp.Ile595Serrs1390260941.65E-05TOLERATED0.6508
c.808A>Cp.Ile270Leurs2014383501.65E-05TOLERATED0.6511
c.331A>Cp.Thr111Prors7595108401.65E-05TOLERATED0.6515
c.1837T>Cp.Cys613Argrs377350683SLCO1B1*301.65E-05TOLERATED0.6571
c.1778C>Gp.Ala593Glyrs7686446331.65E-05TOLERATED0.6588
c.763G>Cp.Val255Leurs7667691401.65E-051008310TOLERATED0.6662
c.145A>Gp.Lys49Glurs7453398381.65E-05TOLERATED0.6715
c.1856C>Tp.Thr619Ilers7604868811.65E-05TOLERATED0.6726
c.1430A>Gp.Asn477Serrs7812117321.65E-05TOLERATED0.6797
c.1664A>Gp.His555Argrs7811115291.65E-05TOLERATED0.6803
c.133G>Ap.Ala45Thrrs5553673341.65E-051008310TOLERATED0.681
c.1781T>Cp.Leu594Prors7617203191.65E-05TOLERATED0.6918
c.527T>Cp.Met176Thrrs5483264401.65E-05TOLERATED0.6921
c.1805G>Tp.Trp602Leurs7781783851.65E-051008220TOLERATED0.6926
c.1589G>Ap.Cys530Tyrrs1847625321.65E-05TOLERATED0.6941
c.1451C>Ap.Pro484Hisrs5689442761.65E-05TOLERATED0.6949
c.610C>Tp.His204Tyrrs7673792481.65E-05TOLERATED0.6953
c.713G>Ap.Gly238Glurs3741135431.65E-051008130TOLERATED0.7046
c.1414C>Tp.Pro472Serrs7465078611.65E-05TOLERATED0.7267
c.1612G>Ap.Val538Ilers7601635041.65E-05TOLERATED0.7384
c.1465T>Ap.Cys489Serrs1447332131.65E-05TOLERATED0.7535
c.222A>Tp.Glu74Asprs7453929939.18E-06TOLERATED0.6631
c.1000A>Tp.Thr334Serrs778714758.75E-06TOLERATED0.6152