Table 3

Renal clearance of fevipiprant and its AG metabolite with and without probenecid

FevipiprantAG Metabolite
ParameterWithout ProbenecidWith ProbenecidWithout ProbenecidWith Probenecid
CLr (l/h)9.91.27.11.7
Glomerular filtration CLr (l/h)0.90.91.81.8
Active CLr (l/h)9.00.35.30
Contribution of active CLr to CLr (%)91%25%75%0