TABLE 1

Mean (CV%) plasma pharmacokinetic parameters of radioactivity, ozanimod, and its metabolites after single oral dose of 1 mg [¹⁴C]ozanimod HCl

PK Parameter (Unit)	Radioactivity	Ozanimod	CC112273	RP101988	RP101075	RP101124
C_max (pg/ml)	1560^{^a} (7.3%)	185 (22.0%)	337 (10.2%)	240 (21.9%)	18.9 (18.1%)	69.8 (27.4%)
T_max (h)^{^b}	10.00 (8.00–24.00)	8.00 (6.00–12.18)	18 (12–36)	8.00 (6.00–12.18)	8.00 (6.00–12.18)	24.00 (24.00–36.02)
AUC_last (pg.h/ml)	116000^{^c} (11.8%)	5400 (29.8%)	31000 (8.20%)	4810 (30.2%)	376 (30.3%)	3480 (27.3%)
AUC_∞ (pg.h/ml)	NR	5690 (28.5%)	NR	5630 (28.5%)	NR	4220 (21.5%), n = 5
t_1/2 (h)	98.61 (13.3%)	20.78 (15.4%)	195 (52.8%), n = 4	15.29 (17.4%)	22.89 (48.2%) n = 4	27.79 (18.6%) n = 5
CL/F (l/h)	NA	192 (36.9%)	NA	NA	NA	NA
V_z/F (l)	NA	5590 (26.6%)	NA	NA	NA	NA

CL/F, apparent total clearance; NA, not applicable; NR, not reportable; V_z/F, apparent volume of distribution.
↵^a Picogram equivalent per milliliter.
↵^b Median (range).
↵^c Picogram equivalent hour per milliliter.