TABLE 2

Metabolite profiles after a single oral dose of 1 mg [14C]ozanimod HCl in healthy subjects

Component[M + H]+MS Fragment IonsPlasma (% of AUC0–96 h for [14C] Related Drug Materials)Feces (% of Dose)Urine (% of Dose)
Ozanimod405344, 302, 188, 157, 1466.70
CC112273360318, 188, 146, 5633.2
RP101124204*160, 13314.55.530.73
RP101988419344, 302, 188, 1466.983.54
RP101075361344, 302, 188, 1465.40
RP101442403344, 302, 188, 157, 146, 60Trace
CC1084037362344, 32, 188, 1465.48
RP112289375333, 171, 1464.69
RP112509376358, 316, 1463.92
RP112402380*204, 175, 117, 11315.70
RP112533162*118, 907.67
RP112480422347, 188, 146, 11512.23
RP112374408347, 188, 146, 1155.30
RP112479421346, 188, 1462.54
M339338*162, 118, 902.58
Total81.030.722.6
  • —, not present (below the threshold for metabolite identification in specified matrix); AUC0–96 h, area under the plasma concentration-time curve from time 0–96 h postdose, * = [M − H] negative mode.