TABLE 3

Metabolite profiles in incubations of 14C-darolutamide (5 µM) with human hepatocytes from three donors (suspension incubation for 3 h, 1 million cells/mL, selected metabolites)

Mean of Total Radioactivity
%
Darolutamide70.7
Keto-darolutamide21.5
M-7a3.7
M-42.2
Othersb1.8

  • ↵a Coelution with two additional hydroxylated metabolites (M-6, M-5).

  • ↵b Comprises M-2, M-3, M-8, and other unidentified compounds.