| | % |
M-1 | Oxidation product (keto-darolutamide) | —b | 0.6 |
M-2 | Hydroxylated and glucuronidated metabolite | 1.3 | —c |
M-7a | O-glucuronide | 23.8 | —c |
M-7b | O-glucuronide | 1.8 | —c |
M-10 | Glucuronidation product of M-1 | 0.6 | —c |
M-15a | N-glucuronide | 5.0 | —c |
M-15b | N-glucuronide | 0.7 | —c |
M-21 | Dealkylated product of oxidative cleavage | 3.2 | —c |
M-22 | Dealkylated product of oxidative cleavage | 3.8 | —c |
M-24 | Dealkylated product of oxidative cleavage | 4.2 | —c |
M-28 | Oxidation product of M-1 | 2.4 | 1.0 |
M-29 | Dealkylated product of oxidative cleavage | 6.2 | —c |
Darolutamide | | 6.7 | 30.3 |
Other | | 3.8 | 0.5 |
% Ae (% of dose) | | 63.4 | 32.4 |