TABLE 2

Plasma concentrations and PK parameters of tropifexor and its metabolites after a single oral dose of 1 mg [¹⁴C]tropifexor to healthy subjects

Time (h)	M11.6^a	M22.4^a	Tropifexor^a
1	0.0773	—^b	1.74
2	0.371	0.240	13.1
4	0.832	1.09	35.1
6	0.483	1.01	27.5
8	0.363	1.37	26.7
12	0.308	1.18	19.0
24	—	0.412	7.45
48	0.150	0.249	2.17
72	—	—	0.987
C_max (ng-eq/ml)	0.832	1.37	35.1
T_max (h)	4	8	4
AUC_0–72h^c (h*ng-eq/ml)	10.4	31.5	576
AUC_inf (h*ng-eq/ml)	NC^d	NC	597
%Total radioactivity AUC_0–72h^e	1.65	5.00	91.6
%Parent AUC_0–72h	1.81	5.46	100

^aThe plasma radioactivity concentrations are expressed in ng-eq/ml.
^bNot detected.
^cCalculated using linear trapezoidal method. The concentrations at time 0 was taken as zero.
^dNot calculated.
^eThe %total radioactivity AUC for each metabolite is calculated based on the total plasma radioactivity AUC_0-72h of 629 h*ng-eq/ml.