Summary statistics of total radioactivity and tropifexor PK parameters in plasma
Statistics are arithmetic mean ± SD (CV%); CV% = S.D./mean*100; for Tmax, statistics are median (Min-Max) total radioactivity.
| PK Parameter (Unit) | Plasma Tropifexor N = 4 | Plasma Total Radioactivity N = 4 |
|---|---|---|
| AUCinf (h*ng/ml)a(h*ng-eq/ml)b | 553 ± 110 (19.9%) | 674 ± 122 (18.1%) |
| AUClast (h*ng/ml)a(h*ng-eq/ml)b | 552 ± 110 (20.0%) | 652 ± 124 (19.1%) |
| Cmax (ng/ml)a(ng-eq/ml)b | 33.5 ± 5.74 (17.2%) | 37.9 ± 7.24 (19.1%) |
| t1/2 (h) | 13.5 ± 2.04 (15.1%) | 20.4 ± 4.49 (22.0%) |
| Tmax (h) | 4.00 (3.00–4.00) | 4.00 (4.00–4.00) |
| CL/F (ml/h) | 1870 ± 439 (23.5%) | |
| Vz/F (ml) | 36,400 ± 10,300 (28.3%) |
aPlasma tropifexor.
bPlasma total radioactivity.