Modulated activity model parameter estimates
Values in brackets represent 95% confidence intervals.
| Parameter | Liver | Kidney | Lung | Vasculature | Intestine | Units |
|---|---|---|---|---|---|---|
| kon | 1.2e8 [3.1e7–4.5e8] | µM-1min-1 | ||||
| koff | 6.2e8 [1.7e8–2.3e9] | 2.4e9 [5.0e8–1.2e10] | min-1 | |||
| kcat,fast | 167 [125–224] | min-1 | ||||
| kinact | 0.35 [0.26–0.46] | 0.16 [0.11–0.23] | 1.1 [0.77–1.5] | min-1 | ||
| kcat,slow | 4.5 [2.6–7.6] | 25 [17–38] | 6.9 [5.2–9.2] | min-1 | ||
| Etissue | 21 [17–26] | 0.038 [0.028–0.050] | 0.043 [0.032–0.059] | 0.072 [0.053–0.098] | 4.7e-3 [3.4e-3–6.5e-3] | pmol/mg S9 |