TABLE 3

Correlation of enzyme expression with enzymatic activities measured with probe substrate reactions

EnzymeReaction/SubstrateSpearman Correlation (rs)n
UGT1A1Dolutegravir0.79562
17β-Estradiol (3OH-glucuronidation)0.78262
Raltegravir0.78379
UGT1A3Chenodeoxycholic acid0.84662
UGT1A4Trifluoperazine0.72962
Lamotrigine0.79362
UGT1A65-Hydroxytryptofol0.85662
UGT1A9Propofol0.51262
Mycophenolic acid0.58779
UGT2B4Gemfibrozil0.43362
Gemfibrozil (with inclusion of UGT2B7 inhibitor)0.37962
UGT2B7Zidovudine0.34462
Ketoprofen0.17262
UGT2B10RO52633970.52932
Amitriptyline0.30832
UGT2B15(S)-Oxazepam0.28363
UGT2B17Testosterone0.58262
CYP1A2Phenacetin O-dealkylation0.83965
Ethoxyresorufin O-deethylation0.80443
CYP2A6Coumarin 7-hydroxylation0.864107
CYP2B6(S)-Mephenytoin N-demethylation0.69684
Bupropion hydroxylation0.91620
CYP2C8Paclitaxel 6α-hydroxylation0.76837
Amodiaquine N-dealkylation0.83064
CYP2C9Diclofenac 4'-hydroxylation0.734107
CYP2C19(S)-Mephenytoin 4'-hydroxylation0.87699
CYP2D6Dextromethorphan O-demethylation0.853107
CYP2E1Chlorzoxazone 6-hydroxylation0.758107
CYP3A4Testosterone 6β-hydroxylation0.923107
Midazolam 1′-hydroxylation0.83763
CYP3A5Testosterone 6β-hydroxylation0.426107
Midazolam 1′-hydroxylation0.55063