TABLE 3

Overview of PK of rifampicin during ex vivo liver perfusion

Values are means ± S.D. (n = 3 for atorvastatin, n = 3 for pitavastatin, and n = 4 for rosuvastatin).

PlasmaBile
AtorvastatinCmax (µg/ml)3.43 ± 1.2563.27 ± 31.08
Tmax (min)15.33 ± 3.6846.67 ± 4.71
AUC120-240 min (µg/ml)328.58 ± 150.185622.59 ± 2934.09
Percent biliary excretion8.39 ± 4.38
PitavastatinCmax (µg/ml)5.09 ± 1.1864.96 ± 1.92
Tmax (min)10.33 ± 2.0530.00 ± 0.00
AUC120-240 min (µg/ml)425.32 ± 111.984690.66 ± 1066.66
Percent biliary excretion7.00 ± 1.59
RosuvastatinCmax (µg/ml)5.53 ± 0.9588.18 ± 7.56
Tmax (min)12.00 ± 1.0035.00 ± 11.20
AUC120-240 min (µg/ml)446.61 ± 49.487284.19 ± 1053.33
Percent biliary excretion10.87 ± 1.57