TABLE 4

Percent biliary excretion of atorvastatin (0.104 mg) metabolites for atorvastatin alone and atorvastatin + rifampicin (n = 1)

Percent Biliary Clearance of MetabolitesAtorvastatinAtorvastatin + RifampicinAUCR
Atorvastatin lactone1.450.170.11
2-Hydroxy atorvastatin3.492.640.76
2-Hydroxy atorva lactone0.070.000.00
4-Hydroxy atorvastatin4.913.330.68
4-Hydroxy atorvastatin lactone0.000.000.00