Physiologic parameters used for scaling CLint and estimating CLAOX contributions
| Tissue | mg S9 Protein/g Tissue | g Tissue/kg b.wt. | Blood Flow Rate | References |
|---|---|---|---|---|
| ml/min/kg | ||||
| Liver | 120 | 21.4 | 20.7 | (Zientek et al., 2010; Cubitt et al., 2011) |
| kidney | 39a | 4.6a | 16.4 | (Obach et al., 2006; Scotcher et al., 2017) |
| Lung | 28a | 10.4a | 77.9 | (Myers et al., 2011; Levitzky, 2013; Scotcher et al., 2017) |
| Vasculature | 8.5b | 14.3 | n/a | (Aird, 2005; Myers et al., 2011) |
| Intestine | 27a | 1.1a,c | 3.54 | (Obach et al., 2006) |
n/a, not applicable
aPersonal communication from XenoTech, LLC
bPersonal communication from BioIVT
cBased on total wet weight of eluted enterocytes