TABLE 2

UGT expression measured for single-donor and 200-donor pooled human liver microsomes by LC-MS/MS.

For single-donor HLM, 10th, 50th (median), and 90th percentiles, and range are presented to describe the study’s population data and mean is presented to compare with the pooled HLM. CV, % for pooled HLM is presented to describe measurement variability and represents n = 4 replicates in one analytical batch.

EnzymeExpression (pmol/mg)
Single-Donor HLM
(n = 130 except for UGT2B10, which was n = 49)
Single-Donor HLM (n = 130)200-Donor Pooled HLM
(n = 4 measurements)
10th PercentileMedian90th PercentileRange
(90:10 percentiles)
MeanMeanCV (%)
UGT1A135.280.71654.710268.58.63
UGT1A32.727.6421.98.19.766.075.70
UGT1A429.167.41143.969.267.97.02
UGT1A68.2419.537.24.523.320.29.45
UGT1A99.2215.026.82.916.215.89.71
UGT2B422.736.159.92.639.831.93.84
UGT2B726.961.21114.166.745.510.0
UGT2B109.9423.844.74.527.512.34.51
UGT2B157.4112.629.74.016.211.022.1
UGT2B170.1700.45513.4794.632.2311.4